The pathway with the name Benzoate (anaerobic)
 has the following structure: 
Result: 
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CC(CCCC(=O)[O-])O)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCCC(=O)[O-])O
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4C(CCCC4=O)O)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CC(CCCC(=O)[O-])O)O
CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCCC(=O)[O-])O
 no rule associatedCC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)O
CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)[O-])O
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4=CC=CC=C4)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4=CCCC=C4)O
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4C(CCCC4O)O)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4C(CCCC4=O)O)O
C1=C(C=CC(=C1)C(=O)[O-])C(=O)[O-]
 SimpleRule(uri = https://envipath.org/package/32de3cf4-e3e6-4168-956e-32fa5ddb0ce1/simple-rule/d6ccc928-0bff-478b-b674-5bb3bb8d319d, SMIRKS = [O-]-[C](=O)-[c;!$(c1(C(=O)[O-])ccccn1)!$(c1(C(=O)[O-])cccnc1):1](:[#6,#7,#8,#16;a:5]):[c:6]>>[#6,#7,#8,#16;a:5]:[c:1]:[c:6]) C1=CC=C(C=C1)C(=O)[O-]
CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)C4C=CCC=C4)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4=CCCC=C4)O
CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)/C=C/CCCC(=O)[O-])O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CC(CCCC(=O)[O-])O)O
C/C=C/C(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)O
 no rule associatedC[C@@H](CC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)O)O
CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)/C=C/CC(=O)[O-])O
 no rule associatedC/C=C/C(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)O
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4=CCCC=C4)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4=CCCCC4O)O
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CCCCCC(=O)[O-])O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)/C=C/CCCC(=O)[O-])O
C1=CC=C(C=C1)C(=O)[O-]
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4=CC=CC=C4)O
CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)C4=CCC=CC4)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4=CCCC=C4)O
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4CCCCC4O)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4CCCCC4=O)O
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4=CCCCC4O)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4C(CCCC4O)O)O
CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)C4=CCCCC4)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4CCCCC4O)O
CC(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)O
 CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCS)O
 no rule associatedCC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)O
CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)[O-])O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)/C=C/CC(=O)[O-])O
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4CCCCC4=O)O
 no rule associatedCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CCCCCC(=O)[O-])O
C[C@@H](CC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)O)O
 no rule associatedCC(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)OP(=O)(O)O)O

Description: Benzoate (or benzoyl-CoA) is the most common intermediate in anaerobic metabolism of aromatic compounds. In the absence of molecular oxygen, the aromatic ring is first reduced prior to ring cleavage. Benzoate is activated to benzoyl-CoA. Dearomatization of the benzene ring is occurs upon a 2 electron reduction of benzoyl-CoA to cyclohex-diene-1-carboxyl-CoA. For subsequent oxidation of cyclohex-diene-1-carboxyl-CoA to 3-hydroxypimelyl-CoA, two metabolic routes are currently discussed, one which involves cyclohex-1-ene-1-carboxyl-CoA as intermediate and another which involves 6-hydroxy-cyclohex-1-ene-1-carboxyl-CoA. For more specific information, see [http://www.ncbi.nlm.nih.gov/pubmed/97144512|Harwood and Gibson (1998)] and [http://www.ncbi.nlm.nih.gov/pubmed/93170297|Koch et al (1993)]. Most studies of anaerobic benzoate degradation have been carried out with the phototrophic bacterium Rhodopseudomonas palustris and with two denitrifying species, Thauera aromatica K172 and Azoarcus evansii (formerly Pseudomonas sp. strain K 172 and KB 740, respectively). Activities of cyclohex-1-ene-1-carboxyl-CoA hydratase, 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase and 2-ketocyclohexane-1-carboxyl-CoA hydrolase were not demonstrated directly. The left side of the reactions from 6-Hydroxycyclohex-1-ene-1-carboxyl-CoA to 3-Hydroxypimelyl-CoA is proposed and has not been identified experimentally. The Pimelyl-CoA degradation from Pimelyl-CoA to Acetyl-CoA is also proposed and most of the enzymes of this sequence do not appear to have been directly assayed. This page shows only anaerobic pathway of benzoate degradation. Its aerobic degradation is documented elsewhere in the EAWAG-BBD.
Your Options:
Update the Pathway Information: POST with (required) pathwayName and (optional) pathwayDescription.
Delete the Pathway: DELETE.
Show nodes: GET on https://envipath.org/package/32de3cf4-e3e6-4168-956e-32fa5ddb0ce1/pathway/d1ec9ff6-b3c2-4da3-b0bb-9af5d032da72/node
Show edges: GET on https://envipath.org/package/32de3cf4-e3e6-4168-956e-32fa5ddb0ce1/pathway/d1ec9ff6-b3c2-4da3-b0bb-9af5d032da72/edge